Antiangiogenic gene therapy
نویسندگان
چکیده
منابع مشابه
Antiangiogenic gene therapy.
In a previous issue of the Proceedings, there are two reports of anti-tumor therapy in mice based on inhibition of angiogenesis by gene therapy. Lin et al. (1) used an adenoviral vector to deliver a recombinant Tie2 receptor that blocked activation of the Tie2 receptor on endothelial cells. A single i.v. injection of this construct resulted in a high circulating level of the soluble receptor pr...
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This short review attempts to demonstrate the usefulness of antiangiogenic gene therapy in achieving inhibition of growth in experimentally-induced metastases. Certain normal tissues (for example skeletal muscle) may be used in vivo, after genetic modification, as a "bioreactor", able to produce and secrete into the bloodstream proteins known to exert antiangiogenic effects. By inhibiting neoan...
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A brief look at AMD and developments which have completely subverted the therapeutic approach to patients affected by this disease. New therapies available include: monoclonal antibody inhibitors of VEGF (Peptaganib, Bevacizumab, Ranibizumab) with the protocols currently in use and a brief reference to new anti-angiogenic therapies that include: decoy of VEGF receptor (VEGF Trap, Small Interfer...
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Antiangiogenic therapy is based upon the fact that tumor vasculature forms from genetically stable endothelial cells that grow into the genetically unstable tumor. Endothelial cells represent attractive targets for therapy, because tumor expansion depends on angiogenesis and endothelial cells are less likely to develop drug resistance than the tumor cells that surround them (1, 2). The findings...
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Currently, antiangiogenic agents are routinely used for the treatment of patients with glioma. However, despite advances in pharmacological and surgical therapy, glioma remains an incurable disease. Indeed, the formation of an abnormal tumor vasculature and the invasion of glioma cells along neuronal tracts are proposed to comprise the major factors that are attributed to the therapeutic resist...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 1999
ISSN: 0969-7128,1476-5462
DOI: 10.1038/sj.gt.3301031